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Synthesis and antibacterial activity of 1,3-diarylpyrimido[4,5-d]pyrimidines
J Cieplik1, J Pluta, O Gubrynowicz
1Department of Organic Chemistry, Medical Academy, Wroclaw, Poland.
Bollettino Chimico Farmaceutico
|August 16, 2003
Abstract:
This paper describes the synthesis of 4,5-diaminoderivatives of pyrimidine and pyrimido [4,5-d] pyrimidines and evaluation of their antibacterial activity on 9 selected bacterial species relatif the changes in the chemical structure to an increase in the bioactive properties.