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Related Experiment Videos

Flow vectorial analysis in an artificial implantable lung.

Akio Funakubo1, Ichiro Taga, John W McGillicuddy

  • 1Department of Electronic and Computer Engineering, Tokyo Denki University, Hiki-Gun, Saitama, Japan.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|August 16, 2003
PubMed
Summary

Researchers developed an artificial implantable lung prototype. Computational fluid dynamics identified flow patterns correlating with thrombus formation, improving device design for patients awaiting lung transplants.

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Area of Science:

  • Biomedical Engineering
  • Medical Devices
  • Cardiovascular Fluid Dynamics

Background:

  • Artificial implantable lungs are crucial for patients awaiting lung transplantation.
  • Device design must address low resistance, adequate gas exchange, plasma impermeability, and nonthrombogenicity.
  • Device geometry significantly influences fluid dynamics and performance.

Purpose of the Study:

  • To design and evaluate artificial implantable lung models using computational fluid dynamics (CFD).
  • To identify geometric configurations that minimize low flow velocity regions.
  • To correlate CFD predictions with in vivo thrombus formation in a prototype.

Main Methods:

  • Utilized CAD to design 10 artificial lung models with specified membrane surface area and port distance.

Related Experiment Videos

  • Applied CFD software to analyze fluid dynamics and predict low flow velocity areas.
  • Conducted an in vivo ovine experiment with a prototype to validate CFD predictions and observe thrombus formation.

    • Main Results:

    • CFD analysis identified specific geometric designs that minimized low flow velocity.
    • In vivo testing confirmed a correlation between predicted low flow areas and observed thrombus formation.
    • Thrombus formation was predominantly observed near the outlet port due to complex flow vector collisions, not just low velocity.

    Conclusions:

    • Computational fluid dynamics, enhanced with microflow vectorial analysis, accurately predicts thrombosis-prone regions in artificial lungs.
    • Understanding complex flow patterns, particularly near the outlet port, is critical for designing safer and more effective artificial implantable lungs.
    • This research advances the development of artificial lungs by linking fluid dynamics to clinical outcomes like thrombosis.