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Plasmapheresis in immunologically mediated polyneuropathies
Dobri D Kiprov1, Jan C Hofmann
1Division of Immunotherapy, California Pacific Medical Center and the Bay Area Mobile Apheresis Program, San Francisco, California, USA. dkiprovcai@aol.com
Summary
Therapeutic plasmapheresis is a common treatment for immune-mediated polyneuropathies like Guillain-Barré syndrome. This procedure remains crucial for managing these neurological disorders, even as new therapies emerge.
Area of Science:
- Neurology
- Immunology
Background:
- Immunologically mediated polyneuropathies are a significant group of neurological disorders.
- Therapeutic plasmapheresis is a widely used treatment modality for these conditions.
Purpose of the Study:
- To review the application of therapeutic plasmapheresis in various immunologically mediated polyneuropathies.
- To highlight the continued relevance of plasmapheresis in managing these conditions.
Main Methods:
- Literature review of studies on therapeutic plasmapheresis for polyneuropathies.
- Discussion of specific conditions including Guillain-Barré syndrome, CIDP, and HIV-associated polyneuropathies.
Main Results:
- Plasmapheresis is effective in treating several immune-mediated polyneuropathies.
- Its role is established in Guillain-Barré syndrome, CIDP, paraproteinemic polyneuropathies, and HIV-associated polyneuropathies.
Conclusions:
- Therapeutic plasmapheresis is a cornerstone treatment for many immunologically mediated polyneuropathies.
- While understanding of pathogenesis evolves, plasmapheresis will likely remain a key therapy.