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Related Experiment Videos

Plasmapheresis in immunologically mediated polyneuropathies.

Dobri D Kiprov1, Jan C Hofmann

  • 1Division of Immunotherapy, California Pacific Medical Center and the Bay Area Mobile Apheresis Program, San Francisco, California, USA. dkiprovcai@aol.com

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|August 16, 2003
PubMed
Summary

Therapeutic plasmapheresis is a common treatment for immune-mediated polyneuropathies like Guillain-Barré syndrome. This procedure remains crucial for managing these neurological disorders, even as new therapies emerge.

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Area of Science:

  • Neurology
  • Immunology

Background:

  • Immunologically mediated polyneuropathies are a significant group of neurological disorders.
  • Therapeutic plasmapheresis is a widely used treatment modality for these conditions.

Purpose of the Study:

  • To review the application of therapeutic plasmapheresis in various immunologically mediated polyneuropathies.
  • To highlight the continued relevance of plasmapheresis in managing these conditions.

Main Methods:

  • Literature review of studies on therapeutic plasmapheresis for polyneuropathies.
  • Discussion of specific conditions including Guillain-Barré syndrome, CIDP, and HIV-associated polyneuropathies.

Main Results:

  • Plasmapheresis is effective in treating several immune-mediated polyneuropathies.

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  • Its role is established in Guillain-Barré syndrome, CIDP, paraproteinemic polyneuropathies, and HIV-associated polyneuropathies.

    • Conclusions:

    • Therapeutic plasmapheresis is a cornerstone treatment for many immunologically mediated polyneuropathies.
    • While understanding of pathogenesis evolves, plasmapheresis will likely remain a key therapy.