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Total synthesis of the potent microtubule-stabilizing agent (+)-discodermolide
Scott S Harried1, Christopher P Lee, Ge Yang
1Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095, USA.
The Journal of Organic Chemistry
|August 16, 2003
Abstract:
The total synthesis of the potent microtubule-stabilizing, antimitotic agent (+)-discodermolide is described. The convergent synthetic strategy takes advantage of the diastereoselective alkylation of a ketone enolate to establish the key C15-C16 bond. The synthesis is amenable to preparation of gram-scale quantities of (+)-discodermolide and analogues.