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Enantioselective Synthesis of L-CCG-I
Subhash P Chavan1, Pallavi Sharma, Rasapalli Sivappa
1Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune 411008, India. spchavan@dalton.ncl.res.in
The Journal of Organic Chemistry
|August 16, 2003
Abstract:
Introduction of natural menthol as the chiral auxiliary in a gamma-Br-alpha,beta-unsaturated ester leads to enantioselective generation of three chiral centers in a single step on reaction with a glycine anion equivalent to provide L-CCG-I in 94% ee.