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[Subacute sclerosing panencephalitis pregnancy].

R Mańko-Juraszek1, S Kasperek

  • 1Oddziału Neurologicznego Wojewódzkiego Szpitala Zespolonego, Bielsku-Białej.

Neurologia I Neurochirurgia Polska
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

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Subacute sclerosing panencephalitis (SSPE) is a rare, fatal neurological disease. This case highlights SSPE's devastating impact during pregnancy, leading to maternal and infant death.

Area of Science:

  • Neurology
  • Virology
  • Immunology

Background:

  • Subacute sclerosing panencephalitis (SSPE) is a rare, progressive neurological disease caused by a persistent measles virus infection.
  • Pregnancy involves natural immunosuppression, potentially reactivating dormant viral infections.

Observation:

  • A 16-year-old pregnant patient presented with behavioral changes, visual agnosia, aphasia, paraparesis, and involuntary movements.
  • Measles virus antibodies in cerebrospinal fluid and disease progression suggested SSPE.
  • The patient died postpartum, with postmortem examination revealing characteristic neuropathological findings of SSPE.

Findings:

  • The case presented is one of the few documented instances of SSPE in pregnant women.
  • Neuropathological examination confirmed SSPE with perivascular inflammatory infiltrates, glial proliferation, and neuronal inclusions.

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  • The pregnancy was terminated, and the premature infant died shortly after birth.

    • Implications:

    • This case underscores the severe risks of SSPE reactivation during pregnancy due to immunosuppression.
    • It suggests a potential role for measles virus mutants in SSPE pathogenesis during pregnancy.
    • Further research into pathogenetic factors and management strategies for SSPE in pregnant women is warranted.