Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The cardiovascular system.

A Moore1, A A Mangoni, D Lyons

  • 1Department of Health Care of the Elderly, Guy's, King's, and St Thomas' School of Medicine, King's College Hospital (Dulwich), East Dulwich Grove, London SE22 8PT, UK. alanmoore@elivefree.net

British Journal of Clinical Pharmacology
|August 16, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microbial players in autoimmunity: multicentric analysis of the association between <i>Mycoplasma hominis</i> serostatus and rheumatoid arthritis.

Microbiology spectrum·2025
Same author

A meta-regression study of the clinical significance of serum aminotransferases in COVID-19.

European review for medical and pharmacological sciences·2021
Same author

Diagnostic Accuracy of Anticarbamylated Protein Antibodies in Established Rheumatoid Arthritis: A Monocentric Cross-Sectional Study.

ACR open rheumatology·2019
Same author

Sex Differences in the Associations between L-Arginine Pathway Metabolites, Skeletal Muscle Mass and Function, and their Responses to Resistance Exercise, in Old Age.

The journal of nutrition, health & aging·2018
Same author

Homoarginine and inhibition of human arginase activity: kinetic characterization and biological relevance.

Scientific reports·2018
Same author

Peripheral blood CD8+ T-cell profiles in patients with psoriatic arthritis: a cross-sectional case-control study.

European review for medical and pharmacological sciences·2017
Same journal

N-acetylcysteine for non-paracetamol-induced acute liver failure in children: A systematic review and meta-analysis.

British journal of clinical pharmacology·2026
Same journal

Anti-seizure medications and DRESS in paediatric patients: A FAERS disproportionality and time-to-onset analysis.

British journal of clinical pharmacology·2026
Same journal

Modelling immune gene expression profiles as pharmacodynamic endpoints of antileishmanial treatment.

British journal of clinical pharmacology·2026
Same journal

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone.

British journal of clinical pharmacology·2026
Same journal

Relationship between continuous infusion meropenem PK/PD target attainment and C-reactive protein dynamics in onco-haematologic patients with febrile neutropenia.

British journal of clinical pharmacology·2026
Same journal

UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx).

British journal of clinical pharmacology·2026
See all related articles

Aging alters cardiovascular responses to drugs, affecting arteries, veins, and the heart. Some age-related cardiovascular changes may be reversible, offering therapeutic potential.

Area of Science:

  • Cardiovascular Physiology
  • Pharmacology
  • Gerontology

Background:

  • Aging significantly impacts the cardiovascular system's response to pharmacological stimuli.
  • Changes affect arterial and venous systems, influencing cardiac afterload and vascular resistance.
  • Key alterations include reduced arterial compliance and altered autonomic nervous system activity.

Purpose of the Study:

  • To review the effects of aging on cardiovascular drug and hormone reactivity.
  • To examine age-related changes in the autonomic nervous system and cardiovascular responses to inotropic agents.
  • To discuss the potential reversibility of age-related cardiovascular changes and their therapeutic implications.

Main Methods:

  • This review synthesizes existing literature on aging and cardiovascular pharmacology.

Related Experiment Videos

  • It focuses on studies investigating drug and hormone effects on arterial and venous systems.
  • Analysis includes research on autonomic nervous system modulation and inotropic agent responses in aging populations.

    • Main Results:

    • Aging leads to decreased large artery compliance and impaired vascular resistance regulation.
    • Sympathetic nervous system activity increases with age.
    • Hemodynamic responses to inotropic agents are diminished in older individuals.

    Conclusions:

    • Aging profoundly alters cardiovascular reactivity to pharmacological agents.
    • Age-related cardiovascular changes, including arterial and venous systems, are complex.
    • Partial reversibility of these changes suggests promising therapeutic avenues for cardiovascular health in aging individuals.