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Updated: Aug 12, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Rules for clinical diagnosis in babies with ambiguous genitalia
Y Low1, J M Hutson,
1Centre for Early Sexual Development, Royal Children's Hospital, Parkville, Victoria, Australia.
Abstract:
Intersex disorders are rare and complex; yet, in each case of genital ambiguity, accurate and expeditious management is required of the clinician. This article reviews the embryology of sexual differentiation, from which some 'rules' of diagnosis are derived. A simplified approach to the interpretation of clinical signs in ambiguous genitalia is presented and discussed.
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