[Observation on the effects of urapidil on hemodynamics in heart dysfunction dogs by thoracic electrical
1Department of Emergency, General Hospital of People's Liberation Army, Beijing 100853, China.
Objective:
To observe the effects of urapidil on hemodynamics in heart dysfunction dogs by thoracic electrical bioimpedance.
Methods:
Sixteen health anesthesia dogs were taken pentobarbital till their hearts dysfunction. Then 10 dogs were taken urapidil injection (4 microg x kg(-1) x min(-1)) and 6 dogs were taken the same doses of normal saline, and heart rate (HR), stroke volume (SV), cardiac output (CO), pre-ejection period (PEP), left ventricular ejection time (LVET), systole time ratio (STR), isovolumic relaxation time (IRT), pulmonary capillary wedge pressure (PCWP), left ventricular end-diastolic pressure (LVEDP), total peripheral resistance (TPR), stroke work (SW) and cardiac work (CW) were continuously monitored by non-invasive hemodynamic monitoring system. Data were recorded at 15 minutes, 30 minutes, 60 minutes, 90 minutes and 120 minutes after dysfunction.
Results:
Compared to the group of normal saline, urapidil could increase CO and SV, shorten PEP and STR, decrease PCWP, LVEDP and TPR, increase SW and CW.
Conclusion:
The change of hemodynamics in heart dysfunction dogs can be observed, non-invasively and accurately, by thoracic electrical bioimpedance. Urapidil can obviously decrease preload and postload of heart, increase CO and myocardial contract potentiality, and improve heart function.
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