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Fgfr mRNA isoforms in craniofacial bone development.

D P C Rice1, R Rice, I Thesleff

  • 1Developmental Biology Programme, Institute of Biotechnology, University of Helsinki, Helsinki, Finland. David.Rice@kcl.ac.uk

Bone
|August 16, 2003
PubMed
Summary
This summary is machine-generated.

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Fibroblast growth factor receptor (FGFR) splicing isoforms show distinct expression patterns in developing mouse craniofacial bones. This research clarifies how FGFRs influence craniofacial growth and development, explaining related disorders.

Area of Science:

  • Developmental Biology
  • Genetics
  • Orthopedics

Background:

  • Mutations in fibroblast growth factor receptors (FGFRs) cause craniofacial developmental abnormalities like chondrodysplasias and craniosynostoses.
  • FGFRs exist as mRNA splicing isoforms with specific functions, ligand binding, and tissue distribution.
  • While FGFR expression is known in early development, isoform-specific roles in craniofacial bone development are less understood.

Purpose of the Study:

  • To investigate the expression patterns of FGFR splicing isoforms in the developing mouse craniofacial region.
  • To correlate these expression patterns with craniofacial bone development and potential disease mechanisms.

Main Methods:

  • Detailed survey of FGFR splicing isoform expression in developing mouse mandible, calvaria, and cranial base.

Related Experiment Videos

  • Analysis focused on key growth centers like the spheno-occipital synchondrosis and mandibular condyle.

    • Main Results:

    • Fgfr1c detected in osteoblastic cells; Fgfr3b and Fgfr3c in chondrocytes of cranial base synchondroses and mandibular condyle.
    • Fgfr2b transcripts found in perichondria of mandibular condyle and cranial base.
    • Fgfr2c highly expressed in differentiating osteoblasts at calvarial bone fronts and also in perichondria.

    Conclusions:

    • Expression patterns suggest distinct and overlapping functions for FGFR -b and -c isoforms.
    • FGFR isoform distribution provides insights into craniofacial growth disturbances seen in genetic disorders and transgenic models.
    • FGFR4 transcripts were observed in developing muscles.