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Updated: Jul 12, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
Marine bacteria associated with sponge as source of cyclic peptides
Salvatore De Rosa1, Maya Mitova, Giuseppina Tommonaro
1Istituto di Chimica Biomolecole CNR, via Campi Flegrei, 34, I-80078 Pozzuoli, Naples, Italy. sderosa@icmib.na.cnr.it
Abstract:
Two bacteria associated with the marine sponge Ircinia variabilis were isolated using commercial and experimental media. The use of media containing marine derived proteins improved the growth of both isolated bacteria, showing that marine bacteria need of marine derived proteins for a better growth. The composition of free and total fatty acids of both strains cultivated under different carbon source was investigated. Several diketopiperazines were isolated from both bacteria and the hypothesis of their role in the bacterial-spongy interaction is discussed.
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