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Plasma homocysteine, angiographically proven coronary artery disease, and wine consumption

Egon Toft1, Vibeke Ellegaard Hansen, Jeppe Hagstrup Christensen

  • 1Department of Cardiology, Aalborg Hospital, Arhus University Hospital, Aalborg, Denmark

European Journal of Internal Medicine
|August 16, 2003
PubMed

Insights

High homocysteine levels are linked to coronary artery disease (CAD). Daily wine consumption showed an inverse correlation with homocysteine, suggesting a potential protective mechanism against CAD.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Nutritional Science

Background:

  • Plasma total homocysteine (p-tHcy) is an established independent risk factor for atherosclerotic vascular disease.
  • Elevated p-tHcy levels are associated with an increased risk of cardiovascular events.
  • Understanding factors influencing p-tHcy is crucial for cardiovascular disease prevention.

Purpose of the Study:

  • To investigate the relationship between plasma total homocysteine (p-tHcy) levels and coronary artery disease (CAD).
  • To examine the association between alcohol intake, specifically wine consumption, and p-tHcy levels in patients with suspected CAD.

Main Methods:

  • A cross-sectional study involving 291 patients undergoing elective coronary angiography for suspected CAD.
  • Data collection included patient questionnaires on alcohol intake and blood samples for p-tHcy measurement.
  • Statistical analysis compared p-tHcy levels based on the presence and severity of CAD, history of myocardial infarction (MI), and alcohol consumption patterns.

Main Results:

  • Patients with CAD exhibited significantly higher p-tHcy levels compared to those without CAD.
  • Individuals with a history of myocardial infarction (MI) had elevated p-tHcy levels.
  • Daily wine consumption was associated with lower p-tHcy levels, independent of age, prior MI, and CAD severity.

Conclusions:

  • Plasma total homocysteine (p-tHcy) levels positively correlate with the presence and severity of coronary artery disease (CAD).
  • Wine consumption demonstrates an inverse correlation with p-tHcy levels.
  • These findings suggest a potential mechanism involving wine consumption in reducing CAD risk.

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