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Updated: Aug 19, 2026

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
Published on: September 25, 2011
[Correlation between integrin alpha5beta1 expression in colorectal carcinomas and the biological behavior of the
Jun Zhou1, Yan-qing Ding, Hong-jun Yang
1Department of Pathology, First Military Medical University, Guangzhou 510515, China.
Objective:
To study the correlation between the expression of integrin alpha5beta1 in colorectal carcinomas and the differentiation and metastasis of the tumor cells.
Methods:
The expression levels of integrin alpha5beta1 were detected immunohistochemically in 81 pairs of cancerous and non-cancerous tissues of patients with colorectal cancer.
Results:
The expression of integrin alpha5beta1 was significantly higher in the samples of colorectal carcinomas, than in non-cancerous tissues (P<0.05). Lower expression levels were detected in moderately or well differentiated colorectal carcinomas than in poorly differentiated ones (P<0.05). No significant relation was noted between the expression of integrin alpha5beta1 and lymph node metastasis of the colorectal carcinomas (P>0.05).
Conclusion:
Alpha5beta1 expression is significantly associated with the carcinogenesis and differentiation of colorectal carcinomas, but not with their lymph node metastasis, and the expression level might be used as a valuable pathological indicator for the carcinogenesis and progression of colorectal carcinomas.
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