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Related Experiment Videos

Diffusion-tensor MR imaging in children with developmental delay: preliminary findings.

Christopher G Filippi1, Doris D M Lin, Apostolos J Tsiouris

  • 1Department of Radiology, New York Presbyterian Hospital-Weill Medical College of Cornell University, NY, USA. sairaallapeikko@yahoo.com

Radiology
|August 16, 2003
PubMed
Summary
This summary is machine-generated.

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Diffusion-tensor MR imaging detects white matter abnormalities in children with developmental delay, even when conventional MRI appears normal. This advanced technique reveals changes in diffusion constant (Dav) and anisotropy.

Area of Science:

  • Neuroimaging
  • Pediatric Neurology
  • Biomedical Engineering

Background:

  • Developmental delay (DD) diagnosis often lacks clear structural abnormalities on conventional MRI.
  • Identifying underlying neurobiological differences in DD is crucial for understanding and treatment.
  • Diffusion-tensor MR imaging (DT-MRI) offers advanced insights into white matter microstructure.

Purpose of the Study:

  • To evaluate the efficacy of DT-MRI in detecting white matter abnormalities in pediatric patients with DD and structurally normal conventional brain MRI.
  • To compare DT-MRI metrics between children with DD and neurodevelopmentally healthy controls.

Main Methods:

  • Twenty pediatric patients diagnosed with DD and 10 age-matched healthy controls underwent brain MRI, including DT-MRI.

Related Experiment Videos

  • Diffusion constant (Dav) and anisotropy were measured in various white matter regions (centrum semiovale, corona radiata, internal capsule, corpus callosum, subcortical white matter).
  • Statistical analysis (one-tailed Student t test) was used to compare DT-MRI values between groups (P <.05).

    • Main Results:

    • Children with DD exhibited significant increases in Dav across all measured white matter structures (P <.001 to <.03).
    • Significant decreases in anisotropy were observed in most white matter tracts of children with DD (P <.001 to <.03), excluding the posterior limb of the internal capsule.
    • These DT-MRI findings indicate microstructural white matter alterations not visible on conventional MRI.

    Conclusions:

    • DT-MRI is effective in depicting white matter microstructural abnormalities in children with developmental delay, even when conventional MRI scans are normal.
    • Increased Dav and decreased anisotropy in white matter tracts are key indicators of underlying pathology in DD.
    • DT-MRI provides valuable diagnostic information beyond conventional imaging for pediatric developmental delay.