Related Experiment Video

Updated: Aug 9, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
06:00

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Published on: May 14, 2016

RBM5/LUCA-15--tumour suppression by control of apoptosis and the cell cycle?

Mirna Mourtada-Maarabouni1, Gwyn T Williams

  • 1School of Life Sciences, Keele University, Keele, Staffs, ST5 5BG, UK.

Thescientificworldjournal
|August 16, 2003
PubMed

Insights

The LUCA-15 gene, located at the 3p21.3 lung cancer locus, regulates apoptosis and cell proliferation. Evidence strongly supports its role as a tumour suppressor gene in lung cancer development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The LUCA-15 gene locus is situated at chromosome 3p21.3, a region frequently altered in lung cancer.
  • This locus encodes multiple alternatively spliced transcripts.
  • These transcripts are known regulators of apoptosis, a critical process in tumourigenesis.

Purpose of the Study:

  • To review and highlight evidence implicating the LUCA-15 locus in cancer regulation.
  • To strengthen the understanding of LUCA-15's tumour suppressor activity.
  • To explore the role of LUCA-15 in controlling apoptosis and cell proliferation.

Main Methods:

  • Literature review of existing studies on LUCA-15.
  • Analysis of evidence linking LUCA-15 to apoptosis and cell proliferation.
  • Evaluation of observations supporting tumour suppressor function.

Main Results:

  • The LUCA-15 locus is strongly implicated in the regulation of apoptosis.
  • Evidence suggests LUCA-15 plays a role in controlling cell proliferation.
  • Observations presented significantly reinforce the hypothesis of LUCA-15 as a tumour suppressor.

Conclusions:

  • The LUCA-15 gene locus is a significant player in the control of apoptosis and cell proliferation.
  • The findings presented provide compelling support for LUCA-15's function as a tumour suppressor gene.
  • LUCA-15 represents a promising target for understanding and potentially treating lung cancer.

More Related Videos

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

Related Concept Videos

Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...