Related Experiment Videos
Early development of multiple epithelial neoplasms in Netherton syndrome
K Krasagakis1, D J Ioannidou, M Stephanidou
1Department of Dermatology, University General Hospital of Heraklion, Heraklion, Greece. krasagak@med.uoc.gr
Dermatology (Basel, Switzerland)
|August 16, 2003
Abstract:
We report a case of Netherton syndrome manifested as congenital ichthyosiform erythroderma, trichorrhexis invaginata and atopy, who in early adulthood developed multiple, aggressive epithelial neoplasms in sun-exposed areas of the skin, in areas with papillomatous skin hyperplasia and at the left parotid region. The occurrence of cutaneous neoplasia has been reported in syndromes with congenital ichthyosis and suggests that the underlying genetic defects may cause the development of cancer in prone patients.