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Related Experiment Videos

High serum circulating telopeptide type I in multinodular goiter.

A Loviselli1, E Rizzolo, R Mastinu

  • 1Endocrinology, Department of Medical Sciences, University of Cagliari, Italy. alovise@pacs.unica.it

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|August 16, 2003
PubMed
Summary

Serum ICTP is a better marker than SHBG for identifying thyroid hormone overexposure in women with endogenous subclinical hyperthyroidism. This study found higher ICTP levels in pretoxic goiter patients compared to controls.

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Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Thyroid Disorders

Background:

  • Subclinical hyperthyroidism poses diagnostic challenges.
  • Serum carboxy-terminal-1-telopeptide (ICTP) and sex hormone-binding globulin (SHBG) are potential biomarkers.
  • Previous research suggests ICTP's sensitivity in exogenous subclinical hyperthyroidism.

Purpose of the Study:

  • To evaluate serum ICTP and SHBG in multinodular goiter with or without endogenous subclinical hyperthyroidism.
  • To compare the efficacy of ICTP and SHBG in identifying peripheral thyroid hormone overexposure.
  • To explore correlations between these markers and thyroid function tests.

Main Methods:

  • Study included 45 women with multinodular goiter, divided into pretoxic goiter and non-toxic goiter groups.

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  • A control group of 36 euthyroid women was included for comparison.
  • Serum ICTP, SHBG, TSH, and FT3 levels were measured and analyzed.

    • Main Results:

    • Serum ICTP was significantly higher in the pretoxic goiter group compared to both non-toxic goiter and control groups.
    • Serum ICTP was also elevated in the non-toxic goiter group compared to controls.
    • Serum SHBG levels did not differ significantly among the three groups.
    • SHBG levels were influenced by menopausal status, unlike ICTP.
    • A weak positive correlation was observed between serum FT3 and ICTP.

    Conclusions:

    • Serum ICTP is a more suitable marker than SHBG for detecting peripheral thyroid hormone overexposure in women with endogenous subclinical hyperthyroidism.
    • ICTP levels reflect the degree of thyroid hormone excess in multinodular goiter.
    • SHBG's utility may be confounded by estrogenic status.