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Related Experiment Videos

Molecular-genetic imaging: a nuclear medicine-based perspective.

Ronald G Blasberg1, Juri Gelovani

  • 1Departments of Neurology and Radiology, Memorial Sloan-Kettering Cancer Center, Box 52, 1275 York Avenue, New York, NY 10021, USA. blasberg@neuro1.mskcc.org

Molecular Imaging
|August 19, 2003
PubMed
Summary

Molecular imaging, particularly nuclear-based techniques, offers new ways to study diseases noninvasively. This approach tracks molecular and cellular processes in living subjects, complementing traditional methods.

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Area of Science:

  • Molecular imaging and molecular-genetic imaging.

Background:

  • Molecular imaging has emerged in the last decade, initially driven by in situ reporter imaging.
  • Noninvasive in vivo molecular-genetic imaging integrates nuclear (PET, gamma camera, autoradiography), magnetic resonance (MR), and optical imaging techniques.
  • This field combines molecular biology, cell biology, and advanced imaging technologies.

Purpose of the Study:

  • To focus on nuclear-based molecular-genetic imaging strategies.
  • To discuss the integration of different imaging modalities.
  • To highlight the value of noninvasive assays for monitoring biological processes.

Main Methods:

  • Categorization of nuclear-based molecular imaging into three strategies: indirect reporter gene imaging, direct imaging of endogenous molecules, and surrogate or bio-marker imaging.

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  • Presentation and discussion of examples for each imaging strategy.
  • Commentary on combining different imaging modalities.

    • Main Results:

    • The rapid growth of in vivo molecular imaging is attributed to existing imaging technologies, molecular and cell biology programs, and interdisciplinary convergence.
    • Development of versatile, sensitive, non-tissue-sampling assays is valuable for monitoring molecular-genetic and cellular processes.
    • Noninvasive imaging provides spatial and temporal insights into diseases, complementing ex vivo assays.

    Conclusions:

    • Nuclear-based molecular imaging offers powerful tools for understanding disease mechanisms.
    • Combining imaging modalities enhances the utility of molecular imaging.
    • Noninvasive molecular imaging will be crucial for future research in animal models and human subjects.