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Blood purification therapies using dextran sulfate cellulose columns Liposorber and Selesorb

Takashi Asahi1, Takashi Yamamoto, Hidetoshi Kutsuki

  • 1Medical Devices Division, Kaneka Corporation, Osaka, Japan.

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|August 19, 2003
PubMed

Liposorber is a column used for plasma purification that adsorbs low-density lipoproteins with high selectivity, while Selesorb is a column that selectively adsorbs anti-DNA antibodies, anticardiolipin antibodies, and immune complexes. Both columns are packed with carriers, where a dextran sulfate ligand is bound to porous cellulose beads. Liposorber is used to treat familial hypercholesterolemia (FH), peripheral arterial disease (PAD), and focal segmental glomerulosclerosis (FGS): Selesorb is used to treat systemic lupus erythematosus (SLE). Treatment utilizing both columns is being used effectively in patients with refractory disease that is resistant to pharmacotherapy.

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