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Related Experiment Videos

Peptide based adsorbers for therapeutic immunoadsorption.

Wolfgang Rönspeck1, Roland Brinckmann, Ralf Egner

  • 1Affina-Immuntechnik GmbH, Berlin, Germany.

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|August 19, 2003
PubMed
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New peptide-based adsorbers offer advantages for immunoadsorption therapy. Globaffin targets immunoglobulins for autoimmune diseases and transplant rejection, while Coraffin targets autoantibodies in dilated cardiomyopathy.

Area of Science:

  • Biotechnology
  • Immunology
  • Medical Devices

Background:

  • Peptide ligands present advantages over native proteins for immunoadsorption.
  • Two novel peptide-based adsorbers, Globaffin and Coraffin, have been developed by covalently coupling peptides to sepharose CL-4B.

Purpose of the Study:

  • To evaluate the efficacy of Globaffin and Coraffin as novel immunoadsorption therapies.
  • To assess the applicability of Globaffin in treating antibody-mediated autoimmune diseases and transplant rejection.
  • To determine the potential of Coraffin for treating idiopathic dilated cardiomyopathy by targeting specific autoantibodies.

Main Methods:

  • Development of Globaffin, an immunoglobulin-binding adsorber independent of antigen specificity.
  • Development of Coraffin, a specific adsorber using peptide ligands mimicking beta1-adrenergic receptor epitopes.

Related Experiment Videos

  • Covalent coupling of peptide ligands to sepharose CL-4B for both adsorbers.

    • Main Results:

    • Globaffin is applicable in transplant recipients and for autoimmune diseases like rheumatoid arthritis, systemic lupus erythematosus, and acute renal transplant rejection.
    • Coraffin specifically targets autoantibodies in idiopathic dilated cardiomyopathy, offering a new therapeutic option.
    • Both adsorbers are compatible with approved apheresis control devices.

    Conclusions:

    • Peptide-based immunoadsorption offers a promising therapeutic avenue with Globaffin and Coraffin.
    • Globaffin provides a broad-spectrum immunoadsorption treatment for various autoimmune conditions and transplant rejection.
    • Coraffin presents a targeted therapy for idiopathic dilated cardiomyopathy, addressing limitations of current medical treatments.