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Trauma as a risk factor for thrombosis in children: a report of three cases
Emel Ozyürek1, Nesrin Beşbaş, Deniz Aslan
1Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Insights
Trauma may be a significant risk factor for childhood thrombosis, a multifactorial disorder. This study identified trauma in 3 of 158 pediatric thrombosis cases, with some also having Factor V Leiden mutation.
Area of Science:
- Pediatric Thrombosis
- Vascular Medicine
- Hematology
Background:
- Thromboembolism in children is a complex condition influenced by various congenital and acquired factors.
- Identifying specific triggers like trauma is crucial for understanding and managing pediatric thrombosis.
- Previous research has suggested a potential link between trauma and the development of thrombosis in pediatric populations.
Observation:
- This study analyzed data from 158 children diagnosed with thrombosis.
- Trauma was identified as a primary risk factor in three pediatric cases.
- Specific thrombotic events included cerebral infarction, cerebral venous thrombosis, inferior vena cava thrombosis, and left renal vein thrombosis.
Findings:
- Trauma was the leading identified risk factor in 3 out of 158 children with thrombosis.
- Two of the trauma-associated cases also exhibited the Factor V Leiden mutation.
- The observed thrombotic events in trauma patients were severe, affecting both cerebral and venous systems.
Implications:
- Trauma should be considered a potential trigger for thrombosis in children, necessitating vigilant monitoring.
- The co-occurrence of trauma and Factor V Leiden mutation highlights the importance of genetic screening in at-risk pediatric patients.
- Further research is warranted to elucidate the mechanisms linking trauma to pediatric thrombosis and optimize preventative strategies.
Abstract:
Thromboembolism is described as a multifactorial disorder including both congenital and acquired risk factors in children. Among these, trauma has been suggested as a possible risk factor for development of thrombosis. In this study, we reviewed the data of 158 children with thrombosis. Trauma was the major risk factor for thrombosis in three children. Cerebral infarction and cerebral venous thrombosis were detected in two patients, and thrombosis of the inferior vena cava and left renal vein in the third. In addition, the factor V Leiden mutation was demonstrated in two trauma patients with thrombosis.