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Dilated cardiomyopathy in Indian children

Shyam S Kothari1, Rajesh A Dhopeshwarkar, Anita Saxena

  • 1Cardiothoracic Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi. kothariss@vsnl.com

Indian Heart Journal
|August 19, 2003
PubMed

Insights

Dilated cardiomyopathy in Indian children has a high infant mortality rate but improves in many diagnosed later. Further research into prognostic factors is needed.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Research

Background:

  • Dilated cardiomyopathy (DCM) in children presents a significant clinical challenge.
  • Understanding its course and prognosis in diverse populations is crucial.

Purpose of the Study:

  • To determine the clinical course and prognosis of dilated cardiomyopathy in Indian children.
  • To identify factors influencing outcomes in pediatric DCM.

Main Methods:

  • Retrospective review of 82 children (under 12 years) with DCM.
  • Analysis of clinical data, laboratory results, and serial echocardiograms.
  • Mean follow-up of 25.09 months.

Main Results:

  • Overall mortality was 11.5%; infants had a 25% mortality rate.
  • Actuarial survival reached 87% at 5 years for those diagnosed after infancy.
  • 59% of patients showed improvement on serial echocardiograms; poor prognostic factors included age <1 year and specific echocardiographic ratios.

Conclusions:

  • Pediatric dilated cardiomyopathy follows a varied clinical course, with high mortality in infants.
  • A significant proportion of children diagnosed beyond infancy experience improvement or recovery.
  • Further investigation into prognostic variables is essential for better management.
Abstract

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