Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Phenyramidol-associated liver toxicity.

Aydin S Köksal¹, Seyfettin Köklü, Levent Filik

¹Department of Gastroenterology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey. dckoksal@hotmail.com

The Annals of Pharmacotherapy

|August 19, 2003

Summary

This case report details a patient who experienced liver damage likely caused by phenyramidol. Symptoms resolved after stopping the drug, suggesting phenyramidol may cause hepatotoxicity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Investigation of Clinical and Laboratory Findings of 40-49-Year-Old Patients With Fatty Pancreas by Magnetic Resonance Imaging and Evaluation of the Potential Relationship With Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD).

Pancreas·2025

Same author

Minimizing Delamination in CFRP Laminates: Experimental and Numerical Insights into Drilling and Punching Effects.

Polymers·2025

Same author

Detection of Blastocystis sp. and Dientamoeba fragilis using conventional and molecular methods in patients with celiac disease.

Parasitology international·2024

Same author

Higher Complications During the Waiting Period for Interval Cholecystectomy in Patients With Mild Biliary Pancreatitis.

Surgical laparoscopy, endoscopy & percutaneous techniques·2022

Same author

C. difficile in COVID-19 Patients: Is It a Colonization Issue?

Digestive diseases and sciences·2021

Same author

Pancreaticobiliary maljunction in Turkish patients: a multicenter case series.

Surgical endoscopy·2021

Area of Science:

Hepatology
Clinical Pharmacology
Drug-Induced Liver Injury

Background:

Phenyramidol is an analgesic and muscle relaxant.
Previous literature did not associate phenyramidol with liver damage.

Observation:

A 70-year-old man presented with elevated liver function tests.
Hepatitis from other causes was ruled out.
Elevated enzymes were attributed to phenyramidol treatment.

Findings:

This is the first reported case of probable phenyramidol-induced hepatotoxicity.
The liver damage was likely idiosyncratic and metabolic.
Liver function normalized after drug discontinuation.

Implications:

Related Experiment Videos

Phenyramidol should be considered a potential cause of hepatotoxicity.

Further research into the mechanism of phenyramidol liver damage is warranted.