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Updated: Aug 2, 2026
An Ex vivo Culture System to Study Thyroid Development
Published on: June 6, 2014
[A preliminary study on the relationship between TF-1 cell apoptosis-related gene 19 and thyroid tumor]
1Department of Endocrinology, Peking University Third Hospital, Beijing 100083, China.
Objective:
To investigate whether TF-1 cell apoptosis-related gene 19 (TFAR19), a novel apoptosis-related protein, is expressed in the tissue of thyroid adenoma (TA) or papillary thyroid carcinoma (PTC) and the cellular location of the expression.
Methods:
Thyroid tumor tissue specimens were obtained from six patients with TA and six patients with PTC by surgical biopsies for pathological diagnosis. Normal peri-tumor thyroid tissue from the six TA patients served as control. Immunohistochemical staining was used to detect TFAR19 expression.
Results:
TFAR19 expression was barely detectable in normal thyroid tissue. However, TFAR19 expression was strongly positive in the thyroid tumor tissue of TA group but negative in that of PTC group.
Conclusion:
Our preliminary data have demonstrated for the first time that TFAR19-related apoptotic pathway is activated in the tumor cells of TA and inhibited in those of PTC. The imbalance between cell apoptosis and proliferation might have an important role in the pathogenesis of PTC.
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