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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Management of chronic heart failure due to systolic left ventricular dysfunction by cardiologist and non-cardiologist
Sinéad P McKee1, Stephen J Leslie, John P LeMaitre
1Cardiology Unit, Department of Medical Sciences, The University of Edinburgh, Western General Hospital, EH4 2XU, Edinburgh, UK.
Insights
Implementation of chronic heart failure (CHF) guidelines is poor, even in university hospitals. Adherence to evidence-based therapies like beta-blockers and spironolactone is low, impacting patient outcomes and hospital admissions.
Area of Science:
- Cardiology
- Clinical Practice Guidelines
- Health Services Research
Background:
- Numerous guidelines exist for chronic heart failure (CHF) diagnosis and management.
- The real-world implementation and impact of these guidelines on patient outcomes remain unclear.
Purpose of the Study:
- To evaluate the adherence to a specific systolic heart failure guideline (Scottish Intercollegiate Guideline Network, number 35) in a university hospital.
- To compare guideline adherence between cardiologists and non-cardiologists.
- To assess the association between guideline adherence and hospital admission rates.
Main Methods:
- Retrospective analysis of case records from 400 patients with a primary CHF diagnosis.
- Assessment of management against the Scottish Intercollegiate Guideline Network (SIGN) 35 guideline.
- Examination of hospital admission data over 17 months.
Main Results:
- Overall guideline adherence was poor, with high use of ACE inhibitors/ARBs (80%) but low use of beta-blockers (32%) and spironolactone (13%).
- Cardiologists demonstrated higher use of beta-blockers and digoxin in sinus rhythm compared to non-cardiologists.
- Increased hospital admissions were associated with age, NYHA status, and higher diuretic prescription, but not overall guideline adherence in multivariable analysis.
Conclusions:
- Evidence-based therapies for CHF are inadequately implemented, even in academic settings.
- Lack of organizational support may hinder complex CHF patient management.
- Further research into barriers and facilitators of guideline implementation is warranted.
Abstract:
There are now a number of guidelines outlining the diagnosis and management of patients with chronic heart failure (CHF). The extent to which these guidelines are used and the effects on patient outcomes are not well known. The aim of this study was to examine the implementation of a heart failure guideline among cardiologist and non-cardiologist physicians in a university hospital setting. Case record data were examined from 400 patients with a primary diagnosis of CHF. Management of these patients was assessed using a systolic heart failure guideline (Scottish Intercollegiate Guideline Network, number 35) as a benchmark. Hospital admission data were examined contemporaneously over a 17-month period to assess associations between adherence to drug therapies and number of admissions. Overall, there was poor adherence to the guideline, with relatively high use of angiotensin-converting enzyme (ACE) inhibitors/angiotensin II receptor blockers (ARBs) (80%), low use of beta-blockers (32%) and digoxin (36%), and very low use of spironolactone (13%). Cardiologists used more beta-blockers (37 vs. 21%, P=0.003) and digoxin in sinus rhythm (18 vs. 5%, P<0.001) than non-cardiologists. Hospital admission rate was individually associated with increasing age, NYHA status, beta-blocker, diuretic and spironolactone prescription (all P<0.001). At multivariable analysis, only age, NYHA status and increased diuretic prescription were associated with more frequent admission (P<0.001, R(2)=0.15). Despite carefully designed guidelines, the implementation of evidence-based therapies for CHF remains inadequate, even in a university hospital environment. This may reflect a lack of organisational developments to facilitate the increasingly complex management of patients with CHF.
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