[A flow cytometric study of the effect of chemotherapy on the lymphocyte population composition in chronic...

Results are described of a study of the population and subpopulation composition of lymphocytes in the course of use monochemotherapy (MTS) and polychemotherapy (PCT) in 60 patients with the tumorous form of B-cell chronic lympholeucosis using flow cytometric analysis. It was shown that cytostatic treatment in this form of hemoblastosis results in a reduction of the absolute number of B-lymphocytes due to reduction of general hemocytosis while the relative content of B-cells remained unchanged in MCT and is increased in PCT. A prolonged scheme of PCT is recommended for clinical use that possesses a distinct antitumour effect as compared with MCT and producing a significantly smaller immunosuppressive effect on the T-cell immune system that other schemes of cytostatic therapy.