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[The effect of the long-term treatment with calcium antagonists on myocardial function in patients with hypertension]
Insights
Verapamil and nifedipine prolonged effects (6-12 months) on heart function in hypertensive patients were studied. High ejection fraction patients showed reduced pumping function and increased early diastolic filling with both drugs.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Hypertensive disease (stage II) affects cardiac function.
- Calcium channel blockers like verapamil and nifedipine are used to manage hypertension.
Purpose of the Study:
- To investigate the prolonged (6-12 months) effects of verapamil and nifedipine on myocardial systolic and diastolic function.
- To assess the impact of these drugs on patients with hypertensive disease and high ejection fraction.
Main Methods:
- Study involved 48 patients with hypertensive disease (stage II).
- Evaluated systolic and diastolic function of the myocardium.
- Monitored effects over a 6-12 month period.
Main Results:
- Both verapamil and nifedipine distinctly reduced pumping heart function in patients with ejection fraction ≥55%.
- The drugs increased the rate of early diastolic filling.
- Arterial pressure reduction occurred via vasodilation or reduced cardiac output.
Conclusions:
- Prolonged use of verapamil and nifedipine can negatively impact systolic function in hypertensive patients with preserved ejection fraction.
- These calcium channel blockers may alter diastolic function and influence blood pressure through varied hemodynamic pathways.
Abstract:
Prolonged effect (6-12 months) of verapamil and nifedipine on the systolic and diastolic function of the myocardium was studied in 48 patients with hypertensive disease (stage II). It was established that in patients with a high ejection fraction (55% and more) the two drugs produce a distinct reduction of the pumping heart function. The two drugs increase the rate of early diastolic filling. They also may reduce the arterial pressure via different hemodynamic mechanisms: vasodilatation or via reduction of cardiac output.