Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Corticosteroids in sepsis: from bench to bedside?

Djillali Annane1, Jean-Marc Cavaillon

  • 1Raymond Poincaré Hospital, School of Medicine Paris Ile de France Ouest, University of Versailles Saint Quentin en Yvelinnes, 92380 Garches, France. djillali.annane@roc.ap-hop-paris.fr

Shock (Augusta, Ga.)
|August 19, 2003
PubMed
Summary

Low-dose corticosteroids, particularly glucocorticoids, show promise in treating septic shock by reducing inflammation and improving cardiovascular function. These treatments may enhance survival rates in patients with corticosteroid insufficiency.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HydrOcortisone and fludRocortisoNe for critical ILLness-related corticosteroid insufficiency (HORNbILL): study protocol for a multicentre randomised placebo-controlled trial.

BMJ open·2026
Same author

Ivermectin for Critically and Noncritically Ill Hospitalized Patients With COVID-19: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP).

Critical care medicine·2026
Same author

High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies.

medRxiv : the preprint server for health sciences·2026
Same author

Rethinking fairness in unsupervised healthcare AI: A methodological scoping review.

Journal of biomedical informatics·2026
Same author

Real-world effectiveness and safety of zilucoplan in patients with anti-AChR myasthenia gravis: A retrospective cohort study in France.

Journal of neuromuscular diseases·2026
Same author

Intermediate dose heparin thromboprophylaxis among critically ill patients with COVID-19: a randomized clinical trial.

Journal of thrombosis and haemostasis : JTH·2026

Area of Science:

  • Critical Care Medicine
  • Endocrinology
  • Pharmacology

Background:

  • Septic shock management is evolving, with renewed interest in corticosteroid therapy.
  • Low-dose corticosteroids have demonstrated promising outcomes, especially in patients with corticosteroid insufficiency.

Purpose of the Study:

  • To review the mechanisms behind the beneficial effects of low-dose corticosteroids in septic shock.
  • To explore the anti-inflammatory and cardiovascular actions of glucocorticoids.

Main Methods:

  • Review of in vitro and in vivo experimental models.
  • Analysis of glucocorticoid effects on pro-inflammatory cytokine production, free radicals, prostaglandins, chemotaxis, and adhesion molecules.
  • Evaluation of cardiovascular effects, including mean blood pressure and pressor sensitivity.

Related Experiment Videos

Main Results:

  • Glucocorticoids exhibit broad anti-inflammatory properties.
  • Glucocorticoids positively impact the cardiovascular system, potentially reducing catecholamine requirements.
  • Low-dose glucocorticoids may improve survival in septic shock patients.

Conclusions:

  • The anti-inflammatory and cardiovascular effects of low-dose glucocorticoids contribute to improved septic shock outcomes.
  • Further investigation into corticosteroid mechanisms is warranted for optimizing septic shock treatment.
  • Low-dose corticosteroids represent a potential therapeutic strategy for improving survival in septic shock.