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Updated: Sep 20, 2026
Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
Published on: July 12, 2018
[Comparison of primary colonic anastomosis and colostomy in experimental localized fecal peritonitis]
Cüneyt Kayaalp1, Müjdat Balkan, Cenk Aydin
1Gülhane Askeri Tip Akademisi, Genel Cerrahi Anabilim Dali, Ankara. cuneytkayaalp@hotmail.com
Background:
To investigate the appropriate surgical method that should be selected in the localized fecal peritonitis due to colonic injuries with 24 hours delay.
Methods:
Colonic injuries were performed in 35 rats and the repairs were carried out after 24 hours. Seven rats (%20) died of generalized peritonitis in this period. The remaining 28 rats in which fecal peritonitis were localized by surrounding organs, were randomized in two groups: colostomy (n=14) and primary anastomosis (n=14). Intraabdominal complications and 15 days mortality were assessed.
Results:
The groups had similar results according to intraabdominal complications. The 15 days survival was 71.4 % for the colostomy group and 78.5 % for the anastomosis group (p=0.31)
Conclusion:
If the injured or perforated colon is surrounded by the organs and so the generalized peritonitis is avoided, primary anastomosis would have similar results with colostomy despite fecal contamination and prolonged intervention time.
