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Changes in urinary monoamine excretion in hyperkinetic children
Marat G Uzbekov1, Eduard Y Misionzhnik
1Department of Brain Pathology, Research Institute of Psychiatry, Poteshnaya 3, Moscow, Russia. uzbekovmg@mtu-net.ru
Insights
Children with severe hyperkinetic syndrome (HKS) show significantly higher L-dopa, dopamine, and adrenaline excretion than those with mild HKS. These findings highlight distinct monoamine metabolism differences crucial for targeted HKS treatment.
Area of Science:
- Neuroscience
- Pediatrics
- Biochemistry
Background:
- Hyperkinetic syndrome (HKS) pathogenesis remains unclear, necessitating further research.
- Understanding monoamine metabolism variations in HKS is crucial for effective treatment strategies.
Purpose of the Study:
- To identify specific monoamine metabolism features differentiating mild and severe hyperkinetic syndrome in children.
- To investigate urinary excretion levels of key monoamine metabolites in pediatric HKS.
Main Methods:
- Collected and analyzed 24-hour urine samples from children aged 7-11 years diagnosed with mild or severe HKS.
- Quantified levels of L-dopa, dopamine, noradrenaline, adrenaline, homovanillic acid, vanillylmandelic acid, and 5-hydroxyindoleacetic acid.
- Employed fluorimetric and chromatographic techniques for precise metabolite measurements.
Main Results:
- Severe HKS exhibited significantly elevated urinary excretion of L-dopa (186% increase), dopamine (201% increase), and adrenaline (160% increase) compared to mild HKS.
- Urinary noradrenaline levels remained comparable between mild and severe HKS groups.
- Demonstrated distinct patterns in monoamine metabolism between the two severity levels of HKS.
Conclusions:
- Significant differences in monoamine metabolism exist between mild and severe forms of hyperkinetic syndrome in children.
- These metabolic distinctions may inform the development of tailored pharmacotherapeutic approaches for varying degrees of HKS severity.
Abstract:
The pathogenetic mechanisms of hyperkinetic syndrome are not clear and need further investigation. The aim of the study was to find certain features of monoamine metabolism that are characteristic of children with hyperkinetic syndrome (HKS) with special regard to different degrees of severity (i.e. mild HKS and severe HKS ). The levels of L-dopa, dopamine, noradrenaline, adrenaline, homovanillic, vanillylmandelic and 5-hydroxyindoleacetic acids were measured in daily urine of children (7-11 years old) with mild and severe HKS using fluorimetric and chromatographic methods. Severe HKS was characterized by a significant increase of L-dopa (by 186%), dopamine (by 201%) and adrenaline (by 160%) excretion but an unchanged excretion of noradrenaline compared with those with mild HKS. The study revealed principle differences in monoamine metabolism between the mild and severe forms of HKS which may be of importance in deciding different pharmacotherapeutic approaches to use in patients with HKS of differing severity.