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Updated: Jun 15, 2026

Monitoring of Systemic and Hepatic Hemodynamic Parameters in Mice
Published on: October 4, 2014
[The effect of analysed hypotensive drugs on certain metabolic parameters]
Anna Miczke1, Danuta Pupek-Musialik, Maciej Cymerys
1Katedra i Klinika Chorób Wewnetrznych i Zaburzeń Metabolicznych w Poznaniu.
Abstract:
The aim of this study was to assess the influence of 3 hypotensive drugs on the metabolic disorders: dyslipidemia, insulin resistance, hyperuricemia. There were 39 patients aged 20-55, with mild-to-moderate essential hypertension. The patients with other serious diseases or treated earlier with cholesterol or uric acid lowering drugs were excluded. Patients were divided into 3 groups, each was treated during 8 weeks with one drug: gr 1--trandolapril (T), gr 2--felodipine ER (F), gr 3--rilmenidine (R). Glucose and insulin in oral glucose tolerance test, I/G proportion, serum lipids and uric acid were tested before and after therapy. The therapy did not influence lipid parameters: LDL, HDL, triglyceride. In the T group there could be observed a significant reduction of total cholesterol value. Examined drugs did not induce changes in serum carbohydrate. The significant reduction of serum uric acid could be observed only after F therapy. Analysed drugs are very useful in therapy of hypertension with metabolic disorders.
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