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Principles of risk assessment.

T W Clarkson1

  • 1School of Medicine and Dentistry, University of Rochester, NY 14642.

Advances in Dental Research
|September 1, 1992
PubMed
Summary

This review explores risk assessment principles for toxicology and therapeutic treatments, applying them to dental materials like amalgam fillings. Mercury exposure from dental amalgam is examined as an illustrative example.

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Area of Science:

  • Toxicology
  • Dental Materials Science
  • Risk Assessment

Background:

  • General toxicology and therapeutic treatment monitoring utilize established risk assessment principles.
  • Dental restorative materials can elicit biological reactions requiring risk evaluation.
  • Mercury exposure from dental amalgam fillings is a relevant case study.

Purpose of the Study:

  • To discuss fundamental risk assessment principles.
  • To outline the application of these principles to biological reactions from dental restorative materials.
  • To illustrate these concepts using mercury exposure from amalgam fillings.

Main Methods:

  • Review of existing risk assessment methodologies in toxicology.
  • Application of these principles to the context of dental materials.
  • Illustrative calculations for mercury exposure from amalgam fillings.

Main Results:

  • Risk assessment principles from general toxicology can be adapted for dental materials.
  • Mercury exposure from amalgam fillings presents a complex scenario for risk evaluation.
  • Calculations serve as illustrations, highlighting the need for comprehensive factor consideration.

Conclusions:

  • Risk assessment frameworks are adaptable to evaluating biological responses to dental materials.
  • Amalgam fillings and mercury exposure exemplify the complexities in dental material risk assessment.
  • Further comprehensive analysis is required beyond illustrative calculations for definitive risk assessment.

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