Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperlipasemia associated with hepatitis C virus.

Boris Yoffe1, Anita S Bagri, Thomas Tran

  • 1Department of Medicine, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA.

Digestive Diseases and Sciences
|August 20, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Concurrent renal amyloid light chain amyloidosis, light chain crystalline podocytopathy and light chain proximal tubulopathy: a case report.

Pathology·2026
Same author

Genomic Surveillance Reveals Emergence and Spread of Macrolide-Resistant Mycoplasma pneumoniae in Australia During the 2023-2024 Epidemic.

The Journal of infectious diseases·2026
Same author

CRISPR-Cas-based diagnostics for point-of-care detection of sexually transmitted infections: a laboratory development and evaluation study.

The Lancet. Microbe·2026
Same author

Characterisation of Bordetella pertussis virulence and macrolide resistance in Australia by targeted culture-independent sequencing: a genomic epidemiology study.

The Lancet. Microbe·2026
Same author

Real-world comparison of GLP-1 agonists versus physical activity in metabolic dysfunction-associated steatotic liver disease.

BMC gastroenterology·2026
Same author

Enhanced Diagnosis of Chronic Antibody-mediated Rejection Using Peritubular Capillary Multilayering.

Transplantation·2025

Hepatitis C virus (HCV) infection is linked to higher lipase levels and potential subclinical pancreatitis. Normalizing lipase levels were observed in responders to interferon-based therapy, suggesting it

Area of Science:

  • Hepatology
  • Gastroenterology
  • Virology

Background:

  • Extrahepatic manifestations of chronic hepatitis C virus (HCV) infection are documented.
  • Hyperlipasemia and pancreatitis have not been previously reported as HCV-related conditions.

Purpose of the Study:

  • To investigate the association between hyperlipasemia and/or pancreatitis with hepatitis C infection.
  • To determine if elevated lipase levels are a significant extrahepatic manifestation of HCV.

Main Methods:

  • Retrospective study of 204 subjects evaluated for hepatitis C.
  • Lipase levels measured at baseline for 103 HCV patients and 41 controls.
  • Comparison of lipase and amylase levels between HCV patients and controls, including those with nonalcoholic liver disease.

Related Experiment Videos

Main Results:

  • 25% of HCV patients had elevated lipase compared to 10% of controls (P=0.04).
  • Mean lipase levels were significantly higher in HCV patients (253 units/liter) versus controls (210 units/liter) (P=0.002).
  • Elevated ALT (>1.5x ULN) showed a significant association with elevated lipase (P=0.02).

Conclusions:

  • Hyperlipasemia and subclinical pancreatitis may be extrahepatic manifestations of HCV infection.
  • Elevated lipase levels in HCV patients should not prevent treatment initiation.
  • Normalization of lipase was observed in HCV patients who responded to interferon-based therapy.