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Related Experiment Videos

Cranial diameter pulsations measured by non-invasive ultrasound decrease with tilt.

Toshiaki Ueno1, Richard E Ballard, Brandon R Macias

  • 1Gravitational Research Branch, Life Science Division, NASA Ames Research Center, Moffett Field, CA, USA. tueno@ucsd.edu

Aviation, Space, and Environmental Medicine
|August 20, 2003
PubMed
Summary
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A new non-invasive ultrasound device effectively measures changes in intracranial pressure (ICP) pulsations. This technology can monitor ICP dynamics in astronauts during spaceflight, addressing a critical gap in understanding microgravity

Area of Science:

  • Space physiology
  • Biomedical engineering
  • Neuroscience

Background:

  • Intracranial pressure (ICP) is implicated in microgravity-induced nausea.
  • Previous ICP monitoring methods were invasive, limiting astronaut studies.
  • Altered gravity effects on ICP remain largely uninvestigated.

Purpose of the Study:

  • To demonstrate the feasibility of a novel non-invasive ultrasound technique for monitoring ICP dynamics.
  • To evaluate changes in ICP pulsations under altered gravitational conditions.
  • To assess the sensitivity of the technique for detecting ICP variations.

Main Methods:

  • Six healthy volunteers were subjected to various head-up and head-down tilt positions.
  • Cranial diameter pulsations were measured non-invasively using a pulsed phase lock loop (PPLL) device.
Keywords:
NASA Discipline CardiopulmonaryNASA Program Biomedical Research and CountermeasuresNon-NASA Center

Related Experiment Videos

  • Arterial blood pressure (ABP) was monitored concurrently using a finger pressure cuff.

    • Main Results:

    • Cranial diameter pulsation amplitudes significantly decreased with increasing head-down tilt angles (p < 0.001).
    • A strong linear relationship was observed between tilt angle and pulsation amplitude (95% CI: 0.862-0.968).
    • Arterial blood pressure pulsations did not exhibit a similar correlation with tilt angle.

    Conclusions:

    • The non-invasive ultrasound technique successfully detected changes in cranial diameter pulsation related to altered gravity.
    • ICP pulsation amplitude appears to decrease with head-down tilt, mirroring the observed cranial diameter pulsation changes.
    • The PPLL device demonstrates sufficient sensitivity for non-invasive ICP pulsation monitoring in dynamic gravitational environments.