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Related Experiment Videos

Sequential changes in hematologic and biochemical parameters in African tick bite fever.

M Jensenius1, P-E Fournier, K B Hellum

  • 1Department of Internal Medicine, Department of Clinical Chemistry, Aker University Hospital, Oslo, Norway. mogens.jensenius@ioks.uio.no

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|August 20, 2003
PubMed
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African tick bite fever (ATBF) causes frequent, mild biological abnormalities, including elevated C-reactive protein (S-CRP) and lymphopenia. These changes are common in travelers with this emerging spotted fever group rickettsiosis.

Area of Science:

  • Infectious Diseases
  • Tropical Medicine
  • Rickettsial Diseases

Background:

  • African tick bite fever (ATBF) is an emerging spotted fever group (SFG) rickettsiosis.
  • It affects international travelers to rural sub-Saharan Africa.

Purpose of the Study:

  • To evaluate sequential changes in biological variables in ATBF patients.
  • To estimate the frequency of abnormalities in commonly measured biological markers.

Main Methods:

  • Studied hemoglobin, leukocyte count, lymphocyte count, platelet count, and serum levels of C-reactive protein (S-CRP), alanine aminotransferase (S-ALAT), and other markers.
  • Analyzed data from 108 patients within the first two weeks of illness before treatment.

Main Results:

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  • Observed significant decreases in leukocyte and lymphocyte counts, and platelet counts.
  • Noted significant increases in S-CRP and S-ALAT levels.
  • Found elevated S-CRP (91.7%), lymphopenia (73.3%), and elevated S-ALAT (40.7%) in the first ten days; most abnormalities were mild.

    • Conclusions:

    • Sequential biological changes in ATBF resemble those in other SFG rickettsioses.
    • Mild abnormalities are common, with elevated S-CRP and lymphopenia being the most consistent findings.