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In vivo evaluation of an electroenzymatic glucose sensor implanted in subcutaneous tissue
K W Johnson1, J J Mastrototaro, D C Howey
1Medical Devices and Diagnostics Division, Lilly Laboratory for Clinical Research, Eli Lilly & Co., Indianapolis, IN 46285.
Biosensors & Bioelectronics
|January 1, 1992
Abstract:
Cleanroom processing techniques have been used to mass-produce flexible, electroenzymatic glucose sensors designed for implantation in subcutaneous tissue. In vitro characterization studies have shown the sensor's performance to be acceptable. Initial in vivo studies were conducted with the sensor implanted in the subcutaneous tissue of rabbits. Sensors implanted in the subcutaneous tissue of normal human subjects showed an excellent correlation between glucose concentrations measured by the sensor and capillary finger sticks measured with a commercial analyzer.