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Pain in patients with multiple sclerosis: a population-based study.

Kristina Bacher Svendsen1, Troels Staehelin Jensen, Kim Overvad

  • 1Danish Pain Research Center, Building 1A, Aarhus University Hospital, Noerrebrogade 44, DK-8000 Aarhus C, Denmark. kristina@akhphd.au.dk.

Archives of Neurology
|August 20, 2003
PubMed
Summary

Pain is common in multiple sclerosis (MS) patients, but not more frequent than in the general population. However, MS-related pain is more intense and impacts daily life significantly.

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Area of Science:

  • Neurology
  • Pain Medicine
  • Epidemiology

Background:

  • Pain is a significant symptom for multiple sclerosis (MS) patients, with prevalence estimates ranging widely from 30% to 90%.
  • Previous research has often lacked comprehensive population samples of MS patients.
  • Understanding pain in MS is crucial for patient care and management.

Purpose of the Study:

  • To determine the prevalence of pain in a population-based sample of individuals with multiple sclerosis (MS).
  • To characterize the clinical features of pain experienced by MS patients.
  • To assess the impact of pain on the daily lives of MS patients compared to a reference group.

Main Methods:

  • A postal survey was conducted in Aarhus County, Denmark.
  • The study included 771 patients with definite MS and 769 individuals from a sex- and age-stratified general population reference group.

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  • Data collected included pain prevalence, intensity, treatment requirements, and interference with daily life.

    • Main Results:

    • Response rates were 81.3% for MS patients and 63.3% for the reference group.
    • Pain prevalence in the preceding month was 79.4% for MS patients and 74.7% for the reference group.
    • MS patients reported significantly higher pain intensity, greater daily analgesic use (24.4% vs 9.0%), and more frequent interference of pain with daily life.

    Conclusions:

    • The overall frequency of reported pain did not differ significantly between MS patients and the general population.
    • However, MS patients experienced more severe pain, required more analgesic treatment, and reported a greater negative impact of pain on their daily functioning.
    • These findings highlight the substantial burden of pain in multiple sclerosis, even if its prevalence is similar to the general population.