Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The theory of case-control studies for early detection programs.

Ori Davidov1, Marvin Zelen

  • 1Department of Statistics, University of Haifa, Mount Carmel, Haifa 31905, Israel. davidov@stat.haifa.ac.il

Biostatistics (Oxford, England)
|August 20, 2003
PubMed
Summary

Case-control studies for evaluating early detection programs yield odds ratios near unity, indicating low statistical power. This research clarifies their theoretical basis and limitations in assessing screening benefits for chronic diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Newborn readmissions and virtual primary care delivery: a population-based case-control study.

BMC primary care·2024
Same author

A novel performance scoring quantification framework for stress test set-ups.

PloS one·2023
Same author

On the use of historical estimates.

Statistical papers (Berlin, Germany)·2023
Same author

Testing for inequality constraints in singular models by trimming or winsorizing the variance matrix.

Journal of the American Statistical Association·2020
Same author

MULTI-CENTER CLINICAL TRIALS: RANDOMIZATION AND ANCILLARY STATISTICS.

The annals of applied statistics·2019
Same author

The Dana-Farber CISNET Model for Breast Cancer Screening Strategies: An Update.

Medical decision making : an international journal of the Society for Medical Decision Making·2018

Area of Science:

  • Epidemiology
  • Biostatistics

Background:

  • Case-control studies are frequently employed to assess the effectiveness of early detection programs for chronic diseases.
  • However, the theoretical underpinnings for using case-control studies in this specific application are not well-established.

Purpose of the Study:

  • To investigate the properties of case-control studies when applied to evaluating early detection programs for chronic diseases.
  • To derive a theoretical expression for the odds ratio that reflects the benefit of screening.

Main Methods:

  • Analysis of an idealized case-control study design.
  • Derivation of the theoretical odds ratio in the context of screening and disease natural history.

Main Results:

  • Case-control studies examining early detection programs tend to produce odds ratios that are very close to 1 (unity).

Related Experiment Videos

  • This proximity to unity suggests that these studies possess inherently low statistical power to detect a true benefit of screening.

    • Conclusions:

    • The theoretical framework indicates that case-control studies may be underpowered for reliably evaluating the benefits of early detection programs.
    • Further development of theoretical models is needed to better understand and potentially improve the application of case-control studies in screening research.