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Dexamphetamine treatment in stroke.

D Long1, J Young

  • 1Department of Elderly Care, St Luke's Hospital, Bradford, UK.

QJM : Monthly Journal of the Association of Physicians
|August 20, 2003
PubMed
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Dexamphetamine may aid stroke recovery when combined with therapy. Further research is needed to confirm its safety and effectiveness in stroke rehabilitation, considering potential mood effects.

Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Pharmacology

Background:

  • Stroke recovery aims to reduce disability and dependency.
  • Animal studies show dexamphetamine enhances brain injury recovery, especially with targeted training.
  • Mechanisms align with human neurophysiological rehabilitation theories.

Purpose of the Study:

  • To review existing literature on dexamphetamine use in acute stroke recovery.
  • To evaluate the potential for further clinical studies on dexamphetamine in stroke rehabilitation.

Main Methods:

  • Literature review of animal studies and human clinical trials.
  • Analysis of four controlled trials on dexamphetamine and stroke therapy.
  • Assessment of safety and tolerability in medically ill patients.

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Main Results:

  • Animal studies suggest dexamphetamine improves recovery with motor training or sensory stimulation.
  • Four controlled trials indicated a trend toward improved outcomes when dexamphetamine was paired with therapy post-ischaemic stroke.
  • Dexamphetamine appears safe and well-tolerated in supervised medically ill patients.

Conclusions:

  • Few clinical studies exist, and they were small and highly selected.
  • Potential confounding effects on mood and depression require investigation.
  • Well-designed studies are necessary to establish dexamphetamine's safety and efficacy in stroke rehabilitation.