Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuroectodermal differentiation from mouse multipotent adult progenitor cells.

Yuehua Jiang1, Dori Henderson, Mark Blackstad

  • 1Stem Cell Institute, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

Proceedings of the National Academy of Sciences of the United States of America
|August 20, 2003
PubMed
Summary

Multipotent adult progenitor cells (MAPCs) from mouse bone marrow can differentiate into midbrain neuron-like cells. This discovery suggests MAPCs as a potential cell source for treating central nervous system disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dried Blood Spot Testing in Confirmed Congenital Cytomegalovirus Discovered by Expanded Targeted Testing.

JAMA otolaryngology-- head & neck surgery·2026
Same author

Single-cell transcriptomics-informed induced pluripotent stem cells differentiation to tenogenic lineage.

eLife·2026
Same author

Contemporary Trends, Characteristics, and Outcomes of Patients Undergoing Percutaneous Coronary Intervention for Stent Thrombosis.

JACC. Cardiovascular interventions·2026
Same author

Use of the Ross Procedure in North America: Relation Between Surgical Volume and Operative Mortality.

Journal of the American College of Cardiology·2026
Same author

Medical thoracoscopy with talc poudrage and indwelling pleural catheter insertion versus medical thoracoscopy with talc poudrage alone for patients with symptomatic malignant pleural effusion (TACTIC): a randomised, controlled phase 3 trial.

The Lancet. Respiratory medicine·2026
Same author

A comprehensive outside-of-school intervention to promote school attendance and achievement during the COVID-19 pandemic.

Public health in practice (Oxford, England)·2026

Area of Science:

  • Stem cell biology
  • Neuroscience
  • Developmental biology

Background:

  • Multipotent adult progenitor cells (MAPCs) are rare bone marrow cells.
  • MAPCs can be expanded extensively and differentiate into various cell types.
  • Previous studies showed MAPC differentiation into mesenchymal, endothelial, and endodermal lineages.

Purpose of the Study:

  • To investigate the potential of mouse MAPCs (mMAPCs) to differentiate into neuronal cells.
  • To explore the role of astrocyte-derived factors in mMAPC neuronal differentiation.
  • To compare the differentiation process of mMAPCs to neurons with that of embryonic and neural stem cells.

Main Methods:

  • Expansion of murine MAPCs (mMAPCs) in vitro.
  • Co-culturing mMAPCs with astrocytes to induce neuronal differentiation.

Related Experiment Videos

  • Assessing anatomical and electrophysiological characteristics of differentiated cells.
  • Comparing differentiation pathways with embryonic and neural stem cells.

    • Main Results:

    • mMAPCs were successfully induced to differentiate into cells with neuronal characteristics.
    • Differentiated cells exhibited anatomical and electrophysiological properties similar to midbrain neurons.
    • Neuronal differentiation was facilitated by co-culture with astrocytes, suggesting astrocyte-derived factors are involved.
    • The differentiation process mirrored developmental steps observed in embryonic and neural stem cells.

    Conclusions:

    • mMAPCs can be differentiated into functional neuron-like cells.
    • Astrocyte-derived factors play a crucial role in promoting neuronal differentiation of MAPCs.
    • MAPCs represent a promising cell source for regenerative medicine approaches targeting central nervous system disorders.