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A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice
Paul Denny1, Elaine Hopes, Neill Gingles
1MRC UK Mouse Genome Centre & Mammalian Genetics Unit, Harwell, Oxon, OX11 0RD, UK. paul@har.mrc.ac.uk
Abstract:
We have studied the genetics of susceptibility to infection by Streptococcus pneumoniae in mice. Linkage analysis of the F(2) generation from a cross between resistant BALB/cO1aHsd and susceptible CBA/CaO1aHsd strains allowed us to map a major locus controlling the development of bacteremia and survival after intranasal infection.