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Summary
Fosfomycin is quickly absorbed and excreted, with higher concentrations found in the kidney. Urinary recovery rates varied significantly between oral (20%) and intravenous (90%) administration routes.
Area of Science:
- Pharmacokinetics
- Antibiotic Research
- Drug Metabolism
Background:
- Fosfomycin is a broad-spectrum antibiotic used to treat various bacterial infections.
- Understanding its absorption and excretion is crucial for optimizing therapeutic efficacy.
- Previous studies have established baseline pharmacokinetic profiles for fosfomycin.
Purpose of the Study:
- To summarize and report the absorption and excretion of fosfomycin in patients.
- To compare pharmacokinetic data from oral and intravenous administration routes.
- To investigate fosfomycin concentration in renal tissue.
Main Methods:
- Data compilation from Japanese hospitals and institutions.
- Analysis of absorption and excretion patterns post-administration.
- Measurement of drug concentrations in urine, blood, and kidney tissue.
Main Results:
- Fosfomycin demonstrated rapid absorption and urinary excretion after both oral and intravenous administration.
- Six-hour urinary recovery rates were approximately 20% for oral and 90% for intravenous routes.
- Elevated concentrations were observed in the kidney, decreasing as blood levels fell. Maximum blood concentration after a 500 mg oral dose in adults was about 3 µg/ml.
Conclusions:
- Fosfomycin exhibits predictable pharmacokinetic behavior, consistent with prior research.
- The route of administration significantly impacts urinary recovery rates.
- Kidney accumulation suggests potential for effective treatment of renal infections.