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Oral UFT and cyclophosphamide combination chemotherapy for metastatic breast cancer
Yoshinari Ogawa1, Tetsuro Ishikawa, Sung-Haw Chung
1Department of Surgery, Osaka City General Hospital, Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Background:
Effective long-term chemotherapy yielding good quality of life is essential. The clinical benefits of oral UFT and cyclophosphamide (CPA) combination chemotherapy for metastatic breast cancer (MBC) were evaluated.
Patients And Methods:
Twenty cases with MBC were enrolled. The mean age was 54 years. Five cases had loco-regional and others had distant metastasis. Nineteen cases had previous therapies. Daily treatment consisted of UFT (300 to 400 mg/body) and CPA (100 to 150 mg/body), both given orally.
Results:
The treatment period ranged from 4 to 80 weeks. The response rate was 35%, while it was 65% in the "stable disease > 6 months" category. The mean time to the first sign of response was 7 weeks and the time to tumor progression was 37 weeks. The frequent adverse effects were leukocytopenia (55%) and gastrointestinal symptoms (35%). The incidence of adverse grade > or = 3 effects was 25%.
Conclusion:
Oral UFT and CPA combination chemotherapy may be suitable for MBC.