[Therapy of synchronous multiple primary malignancies]

The data on 526 patients treated for primary multiple synchronous malignancies were evaluated. The total number of detected tumors was 1,069; concomitant pathology was identified in 377 out of 490 (76.9 +/- 1.9%). Removal of all synchronous tumors was considered radical--and palliative or symptomatic when, whatever the modality, two or at least one tumor was treated. Most of primary multiple synchronous tumors were removed radically (56.4 +/- 2.3%). The best results were obtained when combined therapy was used for early-stage tumors while surgical treatment of advanced cancer was complemented with radiochemotherapy. Radical treatment was contraindicated in 30.3 +/- 3.8% because of concomitant pathology.