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Summary
This study shows fosfomycin combined with ampicillin or gentamicin is effective against pneumococcal meningitis. Antibiotic treatment eradicated pneumococcus from cerebrospinal fluid in all patients, leading to clinical cures in most cases.
Area of Science:
- Infectious Diseases
- Microbiology
- Pharmacology
Background:
- Pneumococcal meningitis remains a significant cause of morbidity and mortality.
- Antibiotic resistance necessitates evaluation of alternative treatment strategies.
Purpose of the Study:
- To evaluate the efficacy and safety of fosfomycin in combination with ampicillin or gentamicin for treating pneumococcal meningitis.
- To determine antibiotic concentrations in plasma and cerebrospinal fluid (CSF).
Main Methods:
- A study involving 12 patients with pneumococcal meningitis.
- In vitro sensitivity testing of pneumococci to fosfomycin, ampicillin, and gentamicin.
- Determination of antibiotic concentrations in plasma and CSF.
- Clinical outcome assessment.
Main Results:
- All 17 pneumococcal isolates were sensitive to fosfomycin and ampicillin; 7 were sensitive to gentamicin.
- Combination therapy with fosfomycin demonstrated eradication of pneumococcus from CSF in all patients.
- Clinical cures were observed in 10 out of 12 patients.
Conclusions:
- Fosfomycin in combination with ampicillin or gentamicin is a viable treatment option for pneumococcal meningitis.
- The combination therapy effectively clears pneumococcus from the CSF, leading to favorable clinical outcomes.