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Breast cancer in association with thyroid disorders
Orhan Turken1, Yavuz NarIn, Sezai DemIrbas
1GATA Haydarpasa Training Hospital, Medical Oncology Department, KadIkoy, Istanbul, Turkey. oturken@hotmail.com
Breast Cancer Research : BCR
|August 21, 2003
Summary
Breast cancer patients show a higher prevalence of both autoimmune and nonautoimmune thyroid diseases. This study investigated thyroid conditions in 150 breast cancer patients compared to 100 controls.
Area of Science:
- Endocrinology
- Oncology
Background:
- The link between breast cancer and thyroid disease remains debated, with conflicting research findings.
- Investigating the prevalence of various thyroid conditions in breast cancer patients is crucial.
Purpose of the Study:
- To determine the incidence of autoimmune and nonautoimmune thyroid diseases in breast cancer patients.
- To compare thyroid disease prevalence in breast cancer patients versus healthy controls.
Main Methods:
- Evaluated 150 breast cancer patients and 100 controls using clinical and ultrasound thyroid examinations.
- Measured serum thyroid hormone and antibody levels, including anti-thyroid peroxidase antibodies.
- Performed fine-needle aspiration for thyroid gland assessment.
Main Results:
- Breast cancer patients exhibited significantly higher anti-thyroid peroxidase antibody levels (P = 0.030).
- Autoimmune thyroid disease incidence was higher in breast cancer patients (38% vs. 17%, P = 0.001).
- Nonautoimmune thyroid disease incidence was also elevated in breast cancer patients (26% vs. 9%, P = 0.001).
Conclusions:
- Findings suggest an increased prevalence of both autoimmune and nonautoimmune thyroid diseases in individuals with breast cancer.