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Risk of relapse after meningococcal C conjugate vaccine in nephrotic syndrome

A S Abeyagunawardena1, D Goldblatt, N Andrews

  • 1Nephrourology Unit, Institute of Child Health, London, UK.

Lancet (London, England)
|August 21, 2003
PubMed

Insights

The meningococcal C conjugate vaccine (MCCV) was offered to UK children. In nephrotic syndrome patients, MCCV significantly increased relapse rates, warranting careful consideration for vaccination.

Area of Science:

  • Pediatric Nephrology
  • Immunology
  • Vaccinology

Background:

  • Nephrotic syndrome is a kidney disorder affecting children.
  • Meningococcal C conjugate vaccine (MCCV) was introduced in the UK in 1999 for all children under 18.
  • The impact of MCCV on children with nephrotic syndrome was not previously well-established.

Purpose of the Study:

  • To investigate the effect of meningococcal C conjugate vaccine (MCCV) on the relapse rate in children with nephrotic syndrome.

Main Methods:

  • A cohort of 106 children diagnosed with nephrotic syndrome was studied.
  • Relapse rates were compared during the 12 months before and the 12 months after MCCV administration.

Main Results:

  • A total of 63 relapses were recorded in the 12 months preceding vaccination.
  • The number of relapses increased to 96 in the 12 months following MCCV administration.
  • This increase in relapse rate was statistically significant (p=0.009).

Conclusions:

  • Administration of the meningococcal C conjugate vaccine (MCCV) was associated with a significant increase in the relapse rate of nephrotic syndrome in children.
  • The decision to vaccinate children with nephrotic syndrome using MCCV requires careful consideration due to this observed effect.

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