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Mutation landscapes.

Akira Sasaki1, Martin A Nowak

  • 1Department of Biology, Faculty of Science, Kyushu University Graduate Schools, Fukuoka, 812-8581, Japan.

Journal of Theoretical Biology
|August 21, 2003
PubMed
Summary
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Genomes possess intrinsic mutation rates, not just fitness. Coupling mutation and fitness landscapes enables evolution, leading to optimal mutation rate distributions rather than minimal rates.

Area of Science:

  • Evolutionary biology
  • Theoretical biology
  • Genomics

Background:

  • Traditional evolutionary models assume constant mutation rates.
  • Genomes encode enzymes for replication and error correction, influencing mutation rates.
  • This introduces the concept of mutation landscapes alongside fitness landscapes.

Purpose of the Study:

  • To explore evolutionary dynamics on mutation landscapes.
  • To investigate the interplay between mutation and fitness landscapes.
  • To determine selection pressures on mutation rates in evolving populations.

Main Methods:

  • Theoretical modeling of evolutionary dynamics.
  • Analysis of "mutation landscapes" and "fitness landscapes".
  • Investigating conditions for localization and adaptation.

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Main Results:

  • Pure mutation landscapes offer limited localization possibilities.
  • Coupling mutation and fitness landscapes facilitates localization and adaptation.
  • Selection favors an optimal distribution of mutation rates (mutational quasispecies), not necessarily the minimum rate.

Conclusions:

  • Mutation rates are an evolvable trait, not just a parameter.
  • The interaction between mutation and fitness landscapes is crucial for adaptation.
  • Evolutionary equilibrium selects for a 'mutational quasispecies' balancing mutation and fitness.