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Neuroimaging of serotonin transporters in post-stroke pathological crying
Toshiya Murai1, Henryk Barthel, Jörg Berrouschot
1Max-Planck-Institute of Cognitive Neuroscience, Stephanstr. 1, D-04103 Leipzig, Germany.
Psychiatry Research
|August 21, 2003
Abstract:
Pathological crying (PC) is a neuropsychiatric disorder characterized by an excessive tendency towards crying after brain damage. To elucidate the role of serotonin neurotransmission for PC, a pilot study was performed using single photon emission computed tomography with [123I]beta-CIT to estimate central (midbrain/pons and thalamus/hypothalamus) serotonin transporter (SERT) densities in 15 stroke patients who did or did not have PC. SERT binding ratios in midbrain/pons were significantly lower in the PC subgroup.